中医学报

目的:总结附子的药用原理,扩展其临床应用范围。方法:总结、归纳近年来的相关文献,用现代药理理论研究附子的医用价值与临床新用手段。结果:附子回阳救逆、补阳助火的功效,用现代医学的理论来说,与强心、抗心律失常、扩张血管、增强肾上腺皮质系统的作用直接相关;而散寒作用可以理解为与增强免疫系统、镇痛、增加血氧等作用相关。附子的药效主要体现在其化合物对神经膜蛋白和激素受体的作用,由于二者的作用机理复杂,交互环节很多,难以用单一化合物的药理来解释附子的作用。结论:附子的药理作用复杂,单一成分的作用还有待进一步研究。

Objective:To summarize the officinal principle of Aconitum Carmichaeli Debx and extend its clinical application range.Methods:Related literatures in recent years were summarized and concluded,modern pharmacology theory was used to research the medical value and clinical new-application method of Aconitum Carmichaeli Debx.Results:Aconitum Carmichaeli Debx had the effects of regenerating yang and rescue cold limbs,tonifying yang and adding fire,in terms of modern medical theory,the effects had direct relation with stronging heart,resisting arrhythmia,dilating vessel,enhancing function of adrenal cortex system;dispersing cold effects of Aconitum Carmichaeli Debx could be interpreted as had relationship with stringing immune system,easing pain,increasing blood oxygen.Pesticide effect of Aconitum Carmichaeli Debx was mainly embodied in its compound had effects on neurilemma protein and hormone receptor,and the two objects had complex functional mechanism and multiple interactive links,thus,the effects of Aconitum Carmichaeli Debx could not be explained by single compound.Conclusion:Aconitum Carmichaeli Debx has complex pharmacology function,effect of its single component needs to be further studied.